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Important funding received for a multidisciplinary clinical study on periprosthetic joint infections and antimicrobial resistance

Assoc Prof Margarita Trobos has recently obtained funding from ALF (500 000 SEK/year) and CARe (596 276 SEK) for the period 2020-2022, to carry out a clinical treatment research project that aims to validate a novel diagnostic method that can guide the treatment of periprosthetic joint infections (PJI).The departments of Biomaterials (GU), Orthopaedics (SU/Mölndal) and Infectious Diseases (SU/Östra) are collaborating in this study. Read more

ALF call on Clinical Treatment Research 2020-2022: Treatment of periprosthetic joint infections guided by Minimum Biofilm Eradication Concentration (MBEC) in addition to Minimum Inhibitory Concentration (MIC); a prospective randomized clinical trial
CARe (Center for Antibiotic Resistance Research at GU): Antibiotic resistance in chronic biofilm infections – Novel mechanisms and approaches to the diagnosis and treatment of periprosthetic joint infections
 


An article on the research performed at our department on the topic of biomaterial - associated infections has been recently published in the Swedish newspaper Dagens Industri

ARTICLE


ORAL REGENERATION TOPIC: GUIDED BONE REGENERATION celebrates - 30th anniversary

Key Publication Interview

Nadja Nänni in conversation with Christer Dahlin about his key publication on Guided Bone Regeneration.
Reference: Dahlin C, Sennerby L, Lekholm U, Linde A, Nyman S.: Generation of new bone around titanium implants using a membrane technique: an experimental study in rabbits. Int J Oral Maxillofac Implants. 1989 Spring;4(1):19-25.
The study by Christer Dahlin and his co-authors is a key-publication on Guided Bone Regeneration (GBR), that celebrates already its 30th anniversary in 2019. It describes the first time that a membrane was used with the aim of regenerating bone around implants by providing a secluded space for osteogenesis and to prevent soft-tissue ingrowth. Nadia Nänni talked to Christer Dahlin about this study during a congress in Bern in November 2019. Christer Dahlin explained how the idea for this study was developed, the implications it had, and he shared some personal insights and background information on his early career.
 

Link Interview



Xiaoqin Wang et al recently published in Biomaterials, “Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces”

Titanium is one of the most commonly used material for dental and orthopedic implants. Although the current titanium implants show high survival rate after 10-15 years, there is still a clinical need of novel implants especially for patients with deranged musculoskeletal tissues which exhibit poor regenerative potential. In a recent publication, “Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces” in the journal Biomaterials, by Xiaoqin Wang and co-workers, a novel strategy of surface modification for titanium implants via immobilization of exosomes, is presented.
Exosomes secreted from human mesenchymal stem cells (MSCs) have previously shown to possess both regenerative and immunomodulatory properties. Here, it is demonstrated that immobilization of exosomes on titanium surfaces dramatically accelerate MSC adhesion, spreading and proliferation. These observed effects of immobilized exosomes could be attributed to the presence of abundant cell adhesion molecules and signaling molecules in the MSC exosomal proteome. Given the importance of initial recruitment, adhesion and proliferation of fundamental cellular components, particularly MSCs, at titanium implant surfaces for successful bone regeneration around implants and osseointegration, the current findings suggest a biological approach for the generation of bioactive titanium implants.

Further information: Xiaoqin Wang, PhD



Best Poster award vid den internationella kongressen Osseo 2019 i USA

“Effect of drill parameters on heat generation during osteotomy preparation for bone-anchored hearing systems” by Martin L. Johansson; Hanna Peters; Emelie Lager; Omar Omar, Department of Biomaterials in collaboration with Oticon Medical, was recently presented at 7th International Congress on Bone Conduction Hearing and Related Technologies (Osseo) in Miami Beach, USA, was rewarded Best poster in the category basic research.
The presentation was on the evaluation of a novel drill system, MIPS, for installing bone-anchored hearing aid system (BAHS). The vitro study evaluated the new drill system in terms of cutting performance and explored the role of the irrigation and drilling procedure on the degree of heat generation during drilling. The study demonstrated that the MIPS system is more efficient compared to the control system reflected in a lower drill force and torque. Moreover, the MIPS system was less sensitive to deviations from the recommended drilling procedure as demonstrated by a lower degree of heat generation when irrigation is impaired and the drilling sequence prolonged. The poster may be downloaded here

Johansson M, L, Eriksson T, Omar O. In Vitro and Ex Vivo Evaluation of a Novel Guided Drill System for Bone-Anchored Hearing Implants. Int J Oral Maxillofac Implants. 2019;34(6):e85–e98.

Further information: Martin Johansson, PhD



The Sahlgrenska Academy, University of Gothenburg is one of 7 partners in a recently granted 4-year research project on a novel treatment of osteoarthrosis.

APRICOT project kick-off at the University of Southampton, UK, 11-12 November, 2019

The project is coordinated by the University of Southampton, UK. The project was granted within the prestigious Horizon 2020 EU FET Open Program. The program is open to all disciplines, focussing on groundbreaking fundamental research, having high risk and a potential for a paradigm shift in the field. The successful grants awarded within the FET Open program range between 4% and 12% during the recent years.
 

For more information:
Professor Peter Thomsen
https://www.apricot-project.eu/


Professor Peter Thomsen tilldelas Erna Ebelings pris 2019

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Nu har Svenska Läkaresällskapet (SLS) offentliggjort att Peter Thomsen, professor vid avdelningen för biomaterialvetenskap, är årets mottagare av Erna Ebelings pris 2019.

Han får priset " ..för framstående forskning inom området biomaterial. Forskningen har ett viktigt fokus på de biologiska processer som sker i gränsytan mellan implantat och celler och är mycket betydelsefull vid framtagningen av nya material för implantat. Thomsen uppmärksammas också för att ha byggt upp en stark forskningsinfrastruktur kring sitt område”

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Doctoral thesis presented March 1, 2019 by Xiaoqin Wang

Regenerative effects of mesenchymal stem cell-derived exosomes

Avhandling för medicine doktorsexamen vid Sahlgrenska akademin, institutionen för kliniska vetenskaper, avdelningen för biomaterialvetenskap

Xiaoqin Wang successfully defended her PhD thesis on the 1 of March, 2019. The faculty opponent was Susanne Gabrielsson, Karolinska Institutet, Solna. Supervisors were Peter Thomsen and Karin Ekström
 

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Doctoral thesis presented December 14th by Magdalena Zaborowska

- On the pathogenesis of infections associated with percutaneous osseointegrated orthopaedic implants -

Avhandling för medicine doktorsexamen vid Sahlgrenska akademin, institutionen för kliniska vetenskaper, avdelningen för biomaterialvetenskap

Magdalena N Zaborowska successfully defended her PhD thesis on the 14th of December, 2018. The faculty opponent was Artur Schmidtchen, inst för kliniska vetenskaper, Lunds universitet, Lund. Supervisors were Peter Thomsen, Margarita Trobos and Rickard Brånemark.

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Doctoral thesis presented Mars 9, 2018 by Martin L Johansson

“The percutaneous implant. The effects of design, host site and surgery on the tissue response”

Martin L Johansson successfully defended his PhD thesis on the 9th of March, 2018. The faculty opponent was Professor Dr Johan Wolfaardt Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alberta, Canada. Supervisors were  Peter Thomsen, Bjørn Edwin and Leif Hulten

Läs mer

Doctoral thesis presented September 22, 2017 by Furqan Ali Shah

Osteocytes as indicators of bone quality - multiscale structure-composition characterisation of the bone-implant interface

Furqan Ali Shah successfully defended his PhD thesis on the 22nd of Septemberi, 2017. The faculty opponent was Professor Serena M. Best Department of Materials Science and Metallurgy, University of Cambridge, UK. Supervisors were Anders Palmquist, Peter Thomsen and Aleksandar Matic.

read more

Accepted Papers

Extracellular matrix composition during bone regeneration in the human dental alveolar socket

Furqan A.Shah, Shariel Sayardoust, PeterThomsen, Anders Palmquist

Bone, Volume 127, October 2019, Pages 244-249

Does Smoking Impair Bone Regeneration in the Dental Alveolar Socket?

Furqan A. Shah, Shariel Sayardoust, Omar Omar, Peter Thomsen, Anders Palmquist

Calcified Tissue International

Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration.

Sanz M, Dahlin C, Apatzidou D, Artzi Z, Bozic D, Calciolari E, De Bruyn H, Dommisch H, Donos N6 Eickholz P, Ellingsen JE, Haugen HJ, Herrera D, Lambert F, Layrolle P, Montero E, Mustafa K, Omar O, Schliephake H.

J Clin Periodontol. 2019 Jun;46 Suppl 21:82-91.

“50 years of scanning electron microscopy of bone – A comprehensive overview of the important discoveries made and insights gained into bone material properties in health, disease, and taphonomy”


Shah FA, Ruscsák K, and Palmquist A

Has been accepted for publication in the journal “Bone Research” of the Nature group; impact factor 12.354.

Barrier membranes: more than the barrier effect?

Omar O, Elgali I, Dahlin C, Thomsen P.
J Clin Periodontol. 2019 Jan 22. doi: 10.1111/jcpe.13068. [Epub ahead of print]
PMID: 30667525

Kontaktinformation

Avd för biomaterialvetenskap

Box 412, 405 30 Göteborg

Besöksadress:
Arvid Wallgrens Backe 20, Biotech huset, vån 7

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