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Welcome to the Department of Biomaterials


Important funding received for a multidisciplinary clinical study on periprosthetic joint infections and antimicrobial resistance

Assoc Prof Margarita Trobos has recently obtained funding from ALF (500 000 SEK/year) and CARe (596 276 SEK) for the period 2020-2022, to carry out a clinical treatment research project that aims to validate a novel diagnostic method that can guide the treatment of periprosthetic joint infections (PJI).The departments of Biomaterials (GU), Orthopaedics (SU/Mölndal) and Infectious Diseases (SU/Östra) are collaborating in this study. Read more
 

ALF call on Clinical Treatment Research 2020-2022: Treatment of periprosthetic joint infections guided by Minimum Biofilm Eradication Concentration (MBEC) in addition to Minimum Inhibitory Concentration (MIC); a prospective randomized clinical trial
CARe (Center for Antibiotic Resistance Research at GU): Antibiotic resistance in chronic biofilm infections – Novel mechanisms and approaches to the diagnosis and treatment of periprosthetic joint infections


ORAL REGENERATION TOPIC: GUIDED BONE REGENERATION celebrates - 30th anniversary

Key Publication Interview

Nadja Nänni in conversation with Christer Dahlin about his key publication on Guided Bone Regeneration.

Reference: Dahlin C, Sennerby L, Lekholm U, Linde A, Nyman S.: Generation of new bone around titanium implants using a membrane technique: an experimental study in rabbits. Int J Oral Maxillofac Implants. 1989 Spring;4(1):19-25.
The study by Christer Dahlin and his co-authors is a key-publication on Guided Bone Regeneration (GBR), that celebrates already its 30th anniversary in 2019. It describes the first time that a membrane was used with the aim of regenerating bone around implants by providing a secluded space for osteogenesis and to prevent soft-tissue ingrowth. Nadia Nänni talked to Christer Dahlin about this study during a congress in Bern in November 2019. Christer Dahlin explained how the idea for this study was developed, the implications it had, and he shared some personal insights and background information on his early career.

Link Interview


Xiaoqin Wang et al recently published in Biomaterials, “Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces”

Titanium is one of the most commonly used material for dental and orthopedic implants. Although the current titanium implants show high survival rate after 10-15 years, there is still a clinical need of novel implants especially for patients with deranged musculoskeletal tissues which exhibit poor regenerative potential. In a recent publication, “Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces” in the journal Biomaterials, by Xiaoqin Wang and co-workers, a novel strategy of surface modification for titanium implants via immobilization of exosomes, is presented.
Exosomes secreted from human mesenchymal stem cells (MSCs) have previously shown to possess both regenerative and immunomodulatory properties. Here, it is demonstrated that immobilization of exosomes on titanium surfaces dramatically accelerate MSC adhesion, spreading and proliferation. These observed effects of immobilized exosomes could be attributed to the presence of abundant cell adhesion molecules and signaling molecules in the MSC exosomal proteome. Given the importance of initial recruitment, adhesion and proliferation of fundamental cellular components, particularly MSCs, at titanium implant surfaces for successful bone regeneration around implants and osseointegration, the current findings suggest a biological approach for the generation of bioactive titanium implants.

Further information: Xiaoqin Wang, PhD


Best Poster award vid den internationella kongressen Osseo 2019 i USA

“Effect of drill parameters on heat generation during osteotomy preparation for bone-anchored hearing systems” by Martin L. Johansson; Hanna Peters; Emelie Lager; Omar Omar, Department of Biomaterials in collaboration with Oticon Medical, was recently presented at 7th International Congress on Bone Conduction Hearing and Related Technologies (Osseo) in Miami Beach, USA, was rewarded Best poster in the category basic research.
The presentation was on the evaluation of a novel drill system, MIPS, for installing bone-anchored hearing aid system (BAHS). The vitro study evaluated the new drill system in terms of cutting performance and explored the role of the irrigation and drilling procedure on the degree of heat generation during drilling. The study demonstrated that the MIPS system is more efficient compared to the control system reflected in a lower drill force and torque. Moreover, the MIPS system was less sensitive to deviations from the recommended drilling procedure as demonstrated by a lower degree of heat generation when irrigation is impaired and the drilling sequence prolonged. The poster may be downloaded here

Further information: Martin Johansson, PhD

 

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The Foundation for Biomedical Engineering (Stiftelsen Medicin & Teknik) has awarded the 2019 Henry Wallman prize in Medical Technology to Professor Rickard Brånemark (orthopaedic surgeon), Associate Professor Max Ortiz Catalan (biomedical engineer) and Associate Professor Kerstin Hagberg (physiotherapist), for demonstrating how good collaboration between representatives for different competences can combine basic research with surgery, medical engineering and clinical work, to create products and solutions that can benefit a large group of patients. The team has developed osseointegrated prostheses for patients with amputated limbs, including a new type of upper extremity prosthesis. The new prosthesis is attached in the bone in the amputation stump with an abutment penetrating the skin. The nerve signals that earlier went to the intact arm are registered, the intentions of the patient are detected and the prosthesis is thus controlled. As the team included rehabilitation in their work, the real-life use of the innovative prosthetic solution is ensured. The latter is also strengthened by the formation of Integrum AB, a company that further develops and markets the results.

The prize consists of a diploma and 50.000 SEK to be shared among the winners. The award will be delivered during an official prize ceremony in the Autumn, to be announced by MedTechWest.
Further information: http://www.medtechwest.se/featured/the-winners-of-the-henry-wallman-prize-in-medical-technology-2019/
 


 

 


 

 

Doctoral thesis presented March 1, 2019 by Xiaoqin Wang

Regenerative effects of mesenchymal stem cell-derived exosomes

Xiaoqin Wang successfully defended her PhD thesis on the 1 of March, 2019. The faculty opponent was Susanne Gabrielsson, Karolinska Institutet, Solna. Supervisors were Peter Thomsen and Karin Ekström

Doctoral thesis presented December 14th by Magdalena Zaborowska

- On the pathogenesis of infections associated with percutaneous osseointegrated orthopaedic implants -

Magdalena N Zaborowska
successfully defended her PhD thesis on the 14th of December, 2018. The faculty opponent was Artur Schmidtchen, inst för kliniska vetenskaper, Lunds universitet, Lund. Supervisors were Peter Thomsen, Margarita Trobos and Rickard Brånemark.

Doctoral thesis presented Mars 9, 2018 by Martin L Johansson

“The percutaneous implant. The effects of design, host site and surgery on the tissue response”

Martin L Johansson successfully defended his PhD thesis on the 9th of Mars, 2018. The faculty opponent was Professor Dr Johan Wolfaardt Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alberta, Canada. Supervisors were Peter Thomsen, Bjørn Edwin and Leif Hulten

Accepted Papers

Extracellular matrix composition during bone regeneration in the human dental alveolar socket

Furqan A.Shah, Shariel Sayardoust, PeterThomsen, Anders Palmquist

Bone, Volume 127, October 2019, Pages 244-249


Does Smoking Impair Bone Regeneration in the Dental Alveolar Socket?

Furqan A. Shah, Shariel Sayardoust, Omar Omar, Peter Thomsen, Anders Palmquist

Calcified Tissue International


“50 years of scanning electron microscopy of bone – A comprehensive overview of the important discoveries made and insights gained into bone material properties in health, disease, and taphonomy”
Shah FA, Ruscsák K, and Palmquist A

Has been accepted for publication in the journal “Bone Research” of the Nature group; impact factor 12.354.

Barrier membranes: more than the barrier effect?

Omar O, Elgali I, Dahlin C, Thomsen P.
J Clin Periodontol. 2019 Jan 22. doi: 10.1111/jcpe.13068. [Epub ahead of print]
PMID: 30667525


Osseointegration and current interpretations of the bone-implant interface

Shah FA, Thomsen P, Palmquist A
Acta Biomaterialia (IF: 6.383)


 

Contact Information

Department of Biomaterials

PO Box 412, SE 405 30 Gothenburg, Sweden

Visiting Address:
Arvid Wallgrens Backe 20

Page Manager: Katarina Olinder Eriksson|Last update: 2/3/2020
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