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Welcome to the Department of Biomaterials

 


A mid-term report from the 2019/2020 Osteology Research Scholars

Farah Asa’ad has been a part of the Osteology Foundation since 2015. In the last five years she has participated in two Osteology Research Academies, which took place in Lucerne and Gothenburg. Now she is in the middle of her one-year scholarship with the Foundation. She has discovered that working with the Osteology Foundation can have a huge impact on her career path as a young researcher.

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Chalmers-GU collaboration to detect and combat implant infections 

By combining expertise in materials science and medicine, Professors Martin Andersson (Chalmers), Margarita Trobos (GU) and Peter Thomsen (GU) will develop new methods for detection and eradication of infections on medical implants in a newly established collaboration between Chalmers and the Sahlgrenska Academy at the University of Gothenburg.

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Important funding received for a multidisciplinary clinical study on periprosthetic joint infections and antimicrobial resistance

Assoc Prof Margarita Trobos has recently obtained funding from ALF (500 000 SEK/year) and CARe (596 276 SEK) for the period 2020-2022, to carry out a clinical treatment research project that aims to validate a novel diagnostic method that can guide the treatment of periprosthetic joint infections (PJI).The departments of Biomaterials (GU), Orthopaedics (SU/Mölndal) and Infectious Diseases (SU/Östra) are collaborating in this study. Read more
 

ALF call on Clinical Treatment Research 2020-2022: Treatment of periprosthetic joint infections guided by Minimum Biofilm Eradication Concentration (MBEC) in addition to Minimum Inhibitory Concentration (MIC); a prospective randomized clinical trial
CARe (Center for Antibiotic Resistance Research at GU): Antibiotic resistance in chronic biofilm infections – Novel mechanisms and approaches to the diagnosis and treatment of periprosthetic joint infections


ORAL REGENERATION TOPIC: GUIDED BONE REGENERATION celebrates - 30th anniversary

Key Publication Interview

Nadja Nänni in conversation with Christer Dahlin about his key publication on Guided Bone Regeneration.

Reference: Dahlin C, Sennerby L, Lekholm U, Linde A, Nyman S.: Generation of new bone around titanium implants using a membrane technique: an experimental study in rabbits. Int J Oral Maxillofac Implants. 1989 Spring;4(1):19-25.
The study by Christer Dahlin and his co-authors is a key-publication on Guided Bone Regeneration (GBR), that celebrates already its 30th anniversary in 2019. It describes the first time that a membrane was used with the aim of regenerating bone around implants by providing a secluded space for osteogenesis and to prevent soft-tissue ingrowth. Nadia Nänni talked to Christer Dahlin about this study during a congress in Bern in November 2019. Christer Dahlin explained how the idea for this study was developed, the implications it had, and he shared some personal insights and background information on his early career.

Link Interview


Xiaoqin Wang et al recently published in Biomaterials, “Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces”

Titanium is one of the most commonly used material for dental and orthopedic implants. Although the current titanium implants show high survival rate after 10-15 years, there is still a clinical need of novel implants especially for patients with deranged musculoskeletal tissues which exhibit poor regenerative potential. In a recent publication, “Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces” in the journal Biomaterials, by Xiaoqin Wang and co-workers, a novel strategy of surface modification for titanium implants via immobilization of exosomes, is presented.
Exosomes secreted from human mesenchymal stem cells (MSCs) have previously shown to possess both regenerative and immunomodulatory properties. Here, it is demonstrated that immobilization of exosomes on titanium surfaces dramatically accelerate MSC adhesion, spreading and proliferation. These observed effects of immobilized exosomes could be attributed to the presence of abundant cell adhesion molecules and signaling molecules in the MSC exosomal proteome. Given the importance of initial recruitment, adhesion and proliferation of fundamental cellular components, particularly MSCs, at titanium implant surfaces for successful bone regeneration around implants and osseointegration, the current findings suggest a biological approach for the generation of bioactive titanium implants.

Further information: Xiaoqin Wang, PhD


Best Poster award vid den internationella kongressen Osseo 2019 i USA

“Effect of drill parameters on heat generation during osteotomy preparation for bone-anchored hearing systems” by Martin L. Johansson; Hanna Peters; Emelie Lager; Omar Omar, Department of Biomaterials in collaboration with Oticon Medical, was recently presented at 7th International Congress on Bone Conduction Hearing and Related Technologies (Osseo) in Miami Beach, USA, was rewarded Best poster in the category basic research.
The presentation was on the evaluation of a novel drill system, MIPS, for installing bone-anchored hearing aid system (BAHS). The vitro study evaluated the new drill system in terms of cutting performance and explored the role of the irrigation and drilling procedure on the degree of heat generation during drilling. The study demonstrated that the MIPS system is more efficient compared to the control system reflected in a lower drill force and torque. Moreover, the MIPS system was less sensitive to deviations from the recommended drilling procedure as demonstrated by a lower degree of heat generation when irrigation is impaired and the drilling sequence prolonged. The poster may be downloaded here

Further information: Martin Johansson, PhD

 

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Doctoral thesis presented March 1, 2019 by Xiaoqin Wang

Regenerative effects of mesenchymal stem cell-derived exosomes

Xiaoqin Wang successfully defended her PhD thesis on the 1 of March, 2019. The faculty opponent was Susanne Gabrielsson, Karolinska Institutet, Solna. Supervisors were Peter Thomsen and Karin Ekström

Doctoral thesis presented December 14th by Magdalena Zaborowska

- On the pathogenesis of infections associated with percutaneous osseointegrated orthopaedic implants -

Magdalena N Zaborowska
successfully defended her PhD thesis on the 14th of December, 2018. The faculty opponent was Artur Schmidtchen, inst för kliniska vetenskaper, Lunds universitet, Lund. Supervisors were Peter Thomsen, Margarita Trobos and Rickard Brånemark.

Accepted/Published Papers

Epigenetic changes of osteoblasts in response to titanium surface characteristics

Yuki Ichioka, Farah Asa’ad, Behnosh Öhrnell Malekzadeh, Anna Westerlund, Lena Larsson

Journal of Biomedical Materials Research Part A - Wiley Online Library


An Imbalance of the Immune System Instead of a Disease Behind Marginal Bone Loss Around Oral Implants: Position Paper

Albrektsson T, Dahlin C, Reinedahl D, Tengvall P, Trindade R, Wennerberg A.
Int J Oral Maxillofac Implants. 2020 May/Jun;35(3):495-502. doi: 10.11607/jomi.8218.


Transformation of bone mineral morphology: from discrete marquise-shaped motifs to a continuous interwoven mesh

Shah FA, Ruscsák K, Palmquist A


Sodium salicylate interferes with quorum-sensing-regulated virulence in chronic wound isolates of Pseudomonas aeruginosa in simulated wound fluid

Erik Gerner, Sofia Almqvist, Maria Werthén​, Margarita Trobos​


 


 


 

Contact Information

Department of Biomaterials

PO Box 412, SE 405 30 Gothenburg, Sweden

Visiting Address:
Arvid Wallgrens Backe 20

Page Manager: Katarina Olinder Eriksson|Last update: 5/19/2020
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