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Collagen Scaffolds for Tissue Repair - The "Hole" Story

Research profile seminar

Welcome to our next seminar within our seminar series on Biomaterials and Regenerative Medicine at the Department of Biomaterials.

With the move from tissue replacement to cell-mediated tissue reconstruction and regeneration, there is increasing need for the design of appropriate biomaterial "scaffolds". In order for cells to be able to migrate through a scaffold, it must contain holes of the appropriate dimensions. Our material of choice is collagen, a highly versatile and bioactive natural macromolecule.

To optimise the repair process using collagen scaffolds, it is important to understand the influences on cell behaviour of pore structure and orientation and, also, the interconnections between them. Using freeze drying, it is possible to design the architecture of scaffolds through control of ice crystal formation and growth. This has allowed us to create a range of structures to mimic natural tissue and encourage cell attachment and infiltration. Careful choice of scaffold surface biochemistry also allows us to balance scaffold "activity" and mechanical performance.

This talk will cover the recent work that has been undertaken to optimise the structure and properties of scaffolds for a range of clinical applications in soft tissue repair.

Lecturer: Professor Serena M. Best Department of Materials Science and Metallurgy, Cambridge, UK

Date: 9/21/2017

Time: 2:00 PM - 3:00 PM

Categories: Medicine, Research

Location: Hälsovetarbacken, Arvid Wallgrens Backe
Biotech Center, Dep of Biomaterials (floor7), Arvid Wallgrens backe 20, Gothenburg

Contact person: Karin Ekström

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