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Xiaoqin Wang

Postdoktor

Xiaoqin Wang
Postdoktor
xiaoqin.wang@biomaterials.gu.se

Postadress: Box 412, 40530 Göteborg
Besöksadress: Arvid wallgrens backe 20 , 41346 Göteborg


Avd för biomaterialvetenskap vid Institutionen för kliniska vetenskaper (Mer information)
Box 412
405 30 Göteborg
Besöksadress: Arvid Wallgrens backe 20 , 413 46 Göteborg

Om Xiaoqin Wang

Diputation 2019 - Regenerative effects of mesenchymal stem cell-derived exosomes

Short summary below and link to doctoral thesis

MSC-derived exosomes may be applied as a novel regenerative tool
Mesenchymal stem cells (MSCs) play pivotal roles for bone regeneration by virtue of their osteogenic differentiation ability and immunomodulatory capacity. Recently, secretion of exosomes/extracellular vesicles (EVs) has been suggested as a new mechanism of MSC-based therapy. MSC-derived EVs/exosomes have shown promising effects in tissue regeneration and immunomodulation, which are attributed to their regulatory effects in various processes. The overall objective of this thesis was to explore the cell-to-cell communication and cell-to-material surface interaction mediated by MSC-derived EVs/exosomes. The emphasis was placed on their functions in the regeneration capacity of MSCs and the determination of the microRNA and protein contents of these EVs/exosomes in order to obtain an insight into the underlying mechanisms of the EV-/exosome-mediated biological effects.

- The focus of my research is the small exosomes, secreted by MSCs. We put our efforts to understand the roles of MSC-derived exosomes, particularly shedding light on their effects on proliferation and osteogenic differentiation of MSCs, and also further investigating the underlying mechanisms by exploring the protein and microRNA contents of MSC-derived exosomes, says Xiaoqin Wang, PhD student in Department of Biomaterials.

This research has not yet resulted in any clinical therapy

- However, in the long term it may provide fundamental knowledge for development of novel generation of implants to improve bone regeneration, especially in compromised situations such as osteoporosis, for both dental and orthopedic application.

- We found that MSC-derived exosomes are capable to induce osteogenic differentiation and mineralization of MSCs in a differentiation stage-dependent manner. Both aged MSC- and young MSC-derived exosomes promote proliferation of MSCs in a dose-dependent fashion.

Immobilization of MSC-derived exosomes on titanium surfaces, a commonly used material for dental and orthopedic implants, promote MSC adhesion, growth and osteogenic differentiation on titanium surface. The regenerative effects of MSC-derived exosomes at least partly mediated by the transfer of functional exosome contents including microRNA and proteins. These findings indicate that MSC-derived exosomes may be applied as a novel regenerative tool.

Svensk kort bakgrund- Mesenkymala stamceller (MSC) är en typ av vuxna stamceller som är viktiga för benregeneration (återbildande av benvävnad). MSC kan både differentieras till benceller samt påverka andra celler immunologiskt och på så vis påverka benåteruppbyggnad. Exosomer är en typ av extracellulära vesiklar (EV) som frisätts från celler till miljön utanför cellen och som kan fungera som budbärare mellan celler. De kan interagera med celler i närmiljön eller transporteras i blodet till celler som ligger lite längre bort. EV/exosomer frisätts från de flesta, om inte alla, celler och deras innehåll och funktion är i samklang med vilken celltyp och under vilket stimuli/miljö de frisätts. MSC exosomer har i olika studier bland annat visats påverka olika regenerationsprocesser som benläkning, hjärtregeneration och njurregeneration.
 


 

Senaste publikationer

The Potential Role of Ferroptosis in Neonatal Brain Injury
Y. N. Wu, J. Song, Xiaoqin Wang, C. Culmsee, Changlian Zhu
Frontiers in Neuroscience, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

Altered microRNA expression profile in exosomes derived from mesenchymal stem cells during osteogenic differentiation
Xiaoqin Wang, Omar Omar, Forugh Vazirisani, Peter Thomsen, Karin Ekström
European Cells and Materials, Konferensbidrag (offentliggjort, men ej förlagsutgivet) 2016
Konferensbidrag (offentliggjort, men ej förlagsutgivet)

Mesenchymal stem cells and monocytes communicate via exosomes
Xiaoqin Wang, Omar Omar, Forugh Vazirisani, Peter Thomsen, Karin Ekström
MedTech and Biomaterials, Gothenburg, Sweden, March 4 2014, Poster (konferens) 2014
Poster (konferens)

Exosomes derived from mesenchymal stem cells during osteogenic differentiation induce osteogenic differentiation of mesenchymal stem cells
Xiaoqin Wang, Omar Omar, Forugh Vazirisani, Peter Thomsen, Karin Ekström
International Society of Extracellular Vesicles, Rotterdam, The Netherlands, April 30 – May3 2014, Konferensbidrag (offentliggjort, men ej förlagsutgivet) 2014
Konferensbidrag (offentliggjort, men ej förlagsutgivet)

The emerging role of extracellular vesicles as biomarkers for urogenital cancers.
Muhammad Nawaz, Giovanni Camussi, Hadi Valadi, Irina Nazarenko, Karin Ekström et al.
Nature reviews. Urology, Artikel i vetenskaplig tidskrift 2014
Artikel i vetenskaplig tidskrift

The effect of membrane vesicles from Staphylococcus aureus and Staphylococcus epidermidis on monocytes and macrophages
Forugh Vazirisani, Margarita Trobos, Xiaoqin Wang, Zivko Mladenović, Anders Palmquist et al.
Second International Meeting of ISEV (International Society for Extracellular Vesicles) 2013, April 17-20, Boston, USA. Abstracts, Konferensbidrag (offentliggjort, men ej förlagsutgivet) 2013
Konferensbidrag (offentliggjort, men ej förlagsutgivet)

Visar 1 - 10 av 16

2019

The Potential Role of Ferroptosis in Neonatal Brain Injury
Y. N. Wu, J. Song, Xiaoqin Wang, C. Culmsee, Changlian Zhu
Frontiers in Neuroscience, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

2018

2016

Altered microRNA expression profile in exosomes derived from mesenchymal stem cells during osteogenic differentiation
Xiaoqin Wang, Omar Omar, Forugh Vazirisani, Peter Thomsen, Karin Ekström
European Cells and Materials, Konferensbidrag (offentliggjort, men ej förlagsutgivet) 2016
Konferensbidrag (offentliggjort, men ej förlagsutgivet)

2015

2014

Mesenchymal stem cells and monocytes communicate via exosomes
Xiaoqin Wang, Omar Omar, Forugh Vazirisani, Peter Thomsen, Karin Ekström
MedTech and Biomaterials, Gothenburg, Sweden, March 4 2014, Poster (konferens) 2014
Poster (konferens)

Exosomes derived from mesenchymal stem cells during osteogenic differentiation induce osteogenic differentiation of mesenchymal stem cells
Xiaoqin Wang, Omar Omar, Forugh Vazirisani, Peter Thomsen, Karin Ekström
International Society of Extracellular Vesicles, Rotterdam, The Netherlands, April 30 – May3 2014, Konferensbidrag (offentliggjort, men ej förlagsutgivet) 2014
Konferensbidrag (offentliggjort, men ej förlagsutgivet)

The emerging role of extracellular vesicles as biomarkers for urogenital cancers.
Muhammad Nawaz, Giovanni Camussi, Hadi Valadi, Irina Nazarenko, Karin Ekström et al.
Nature reviews. Urology, Artikel i vetenskaplig tidskrift 2014
Artikel i vetenskaplig tidskrift

2013

The effect of membrane vesicles from Staphylococcus aureus and Staphylococcus epidermidis on monocytes and macrophages
Forugh Vazirisani, Margarita Trobos, Xiaoqin Wang, Zivko Mladenović, Anders Palmquist et al.
Second International Meeting of ISEV (International Society for Extracellular Vesicles) 2013, April 17-20, Boston, USA. Abstracts, Konferensbidrag (offentliggjort, men ej förlagsutgivet) 2013
Konferensbidrag (offentliggjort, men ej förlagsutgivet)

Visar 1 - 10 av 16

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